The lack of evasion and high cost are definite disadvantages, but the evil Jug hits hard and will at least take one or two blockers with him (while possibly leaving a few others permanently crippled)
I've included around eight or so of these effects, which may be too much
In most of your matchups the two life isn't going to matter and at the same time, most of the matchups will also be ones in which Thoughtsieze outperforms other targetted discard effects which is why it remains the best and most played of them

Advanced Search Sets Random Syntax Release date: 2024-10-07 Environmental Sciences Karn, the Great Creator Archon of Emeria Cathar Commando Cathars' Crusade Containment Priest Day of Judgment Deafening Silence Ethersworn Canonist Flickering Ward Iona, Shield of Emeria Kenrith, the Returned King Leyline of Sanctity Path to Exile Prismatic Ending Serra the Benevolent Skyclave Apparition Soul of Theros Spirit of the Labyrinth Stony Silence Temporary Truce Transcendent Master Brain Freeze Consider Daze Displacer Kitten Gitaxian Probe Jace Beleren Mental Misstep Mystical Dispute Narset, Parter of Veils Paradoxical Outcome Ponder Preordain Spell Pierce Treasure Cruise Unnatural Selection Bolas's Citadel Culling the Weak Dead Ringers Faerie Macabre King's Assassin Leyline of the Void Mutilate Pitiless Plunderer Rat Colony Stitcher's Supplier Street Wraith Tendrils of Agony Wishclaw Talisman Worst Fears Ancient Grudge Blazing Rootwalla Chain Lightning Dragon's Rage Channeler Faithless Looting Goblin Guide Rite of Flame Sarkhan, Fireblood Simian Spirit Guide Throes of Chaos Unholy Heat Wish Basking Rootwalla Collector Ouphe Colossal Dreadmaw Elvish Spirit Guide Nature's Claim Noxious Revival Once Upon a Time Sakura-Tribe Elder Seedtime

Bridging the gap between Obsidian Flames and Paradox Rift is the long-awaited Pokemon 151 set